Two studies in this issue of Cell Stem Cell show that splenic extramedullary hematopoiesis in myelofibrosis develops within a remodeled hematopoietic, immune, and stromal environment. Austin et al.1 define its cellular states, whereas Dugué et al.2 reveal the spatial and temporal remodeling of the stromal niche.
Guo-Huan Sun, Tao Cheng· Cell Stem Cell· 0 citations
Mapping how genetic perturbations influence cell fate is key to understanding human development and disease. Here, we developed a massively parallel single-cell CRISPR (scCRISPR) screening platform in primary human hematopoietic stem and progenitor cells (HSPCs), profiling 322 regulators across 172,382 single-perturbed...
A molecular mechanism by which KLF4 governs AML progression is revealed, providing a novel therapeutic target and a potential small-molecule inhibitor for AML treatment.
Meng Yang, Ting Lu, Yi-Cheng He et al.· Leukemia· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.