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Author

Guo-Hui Qin

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2 papers indexed here

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Aug 2026

H2AFY2 suppresses exhaustion and enhances antitumor activity of CAR-T cells through transcriptional and epigenetic modifications.

Chimeric antigen receptor (CAR)-T cell exhaustion constitutes a critical barrier to sustained antitumor efficacy. Through transcriptomic analysis of CAR-T cells from patients with lymphoma, we identified the histone variant macroH2A2 (H2AFY2) as a critical regulator of T cell exhaustion-a finding consistently observed...

C. Li, Qian Wang, Qi-Tai Zhao et al. · 0 citations
Open access Sep 2026

Myeloid-derived suppressor cells confer stemness to esophageal cancer cells through the HNF1A/CXCL1 signaling axis

Our previous work established that myeloid-derived suppressor cells (MDSCs) were abundant in human esophageal squamous cell carcinoma (ESCC) and correlated with adverse prognosis. Yet their direct, T cell-independent impact on tumor propagation remains undefined. Here, we show that MDSCs accelerate ESCC growth in bot...

Guo-Hui Qin, Ping-Chuan Ma, Sha-Sha Liu et al. · 0 citations

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