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Author

Guo-Min Li

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Open access Sep 2026

Mismatch repair protein MLH1 controls testis development by regulating the Hippo-YAP signaling pathway

Abstract DNA mismatch repair (MMR) maintains genomic stability, and defects in MMR genes such as MLH1 and MSH2 predispose to cancer. Unlike other MMR components, MLH1 has unexplained roles in development, as Mlh1-deficient male mice exhibit severe testicular hypoplasia and sterility. Here, we uncover that MLH1 regulate...

Xue-Ying Li, Jia-Jun Yang, Guo-Min Li · 0 citations
Review Jul 2026

The DNA damage response and cancer immunotherapy

This Review examines the molecular mechanisms by which DDR defects potentiate immunotherapy, including recent advances in DDR-targeted combination strategies and discusses mechanisms of resistance, offering a comprehensive perspective on exploiting DDR deficiencies for improved cancer treatment outcomes.

Sheng Hong, Guo-Min Li · 2 citations

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