Author

Guo-Ping Yang

3 papers indexed here

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Open access Aug 2026

A microdose cocktail and population pharmacokinetic study suggests potentially reduced CYP3A and P-gp activities in type 2 diabetes

Background Diabetes patients often exhibit suboptimal efficacy and adverse reactions, accompanied by pharmacokinetic (PK) changes, indicating drug-metabolizing enzymes and transporters (DMET) activities may change. This study aimed to determine whether type 2 diabetes affects DMET activities and quantify impact magnitu...

Ya-Fen Li, Jin Yang, En-Da Zhou et al. · Frontiers in Pharmacology · 0 citations

Open access Sep 2026

Population pharmacokinetic/pharmacodynamic modeling of NH600001 reveals age-related differences in sedation response and supports individualized dosing in elderly patients.

BACKGROUND NH600001 is a novel intravenous anesthetic developed as a safer alternative to etomidate. Its pharmacokinetic/pharmacodynamic (PK/PD) profile and optimal dosing in elderly patients remain insufficiently characterized. This study aimed to develop a population PK/PD model of NH600001 and evaluate age‑related d...

Ya-Jie Cao, Yun Kuang, Qi Gao et al. · Expert Opinion on Drug Metab... · 0 citations

Review Open access Sep 2026

Skin physiologically based pharmacokinetic modeling: current research progress, software comparison, and future perspectives

Abstract Transdermal and topical delivery systems (TDS) have emerged as the third-largest route of administration due to their ability to bypass first-pass metabolism and maintain stable plasma concentrations. Skin physiologically based pharmacokinetic (PBPK) models mechanistically characterize the percutaneous absorpt...

Ya-Fen Li, Yu-Xiao Li, Ya-Xin Liu et al. · Drug Delivery · 0 citations