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Author

G. Chen

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Review Open access Sep 2026

Association Between Sleep Disorders and Breast Cancer: An Analysis Based on NHANES and Mendelian Randomization

Background This study aimed to assess the association between sleep disorders and breast cancer (BC) in the National Health and Nutrition Examination Survey (NHANES) and to evaluate potential causal associations using Mendelian randomization (MR), with separate analyses of estrogen receptor-positive (ER+) and estrogen...

Si-Yan Chen, Jian-Di Li, Ke-Jun Wu et al. · 0 citations
Open access Aug 2026

CRISPR Screen Reveals Pathways and Factors Driving Tyrosine Kinase Inhibitor Resistance in Hepatocellular Carcinoma

Tyrosine kinase inhibitor (TKI) resistance severely limits clinical outcomes in hepatocellular carcinoma (HCC), highlighting the urgent need to elucidate its underlying molecular mechanisms. In this study, an unbiased genome‐wide CRISPR/Cas9 screening identified novel key factors related to the therapeutic responsivene...

Siyi Chen, Li-Hua Yang, Zi-Qian Liang et al. · 0 citations
Open access Jul 2026

A comprehensive study based on large-sample multi-omics integration and machine learning to decode mitochondria-associated genes: from digestive tract tumours to gastric cancer

New insights are provided into the differential expression and pathogenesis of LACTB2 in digestive tract tumours, particularly its prognostic and diagnostic value in GC.

Wei Zhang, Yushan Tang, Yi-Yang Chen et al. · 0 citations

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