Author

Guoshuai Cai

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Open access Oct 2026

Large-scale association study identifies lung cancer susceptibility copy number variants and their potential functional role in genetic instability.

BACKGROUND Genome-wide association studies (GWAS) have identified numerous lung cancer susceptibility loci based on single nucleotide polymorphisms (SNPs), yet a substantial proportion of heritability remains unexplained. We therefore evaluated germline copy number variants (CNVs) as an underexplored source of genetic...

Fei-Fei Xiao, Fei Qin, Xi-Zhi Luo et al. · Cancer Epidemiology, Biomark... · 0 citations

Open access Aug 2026

CDK8/19 inhibition prevents adaptive resistance to CDK4/6 inhibitors in vitro and in vivo

RNA-seq analysis reveals that combining CDK4/6 and CDK8/19 inhibitors suppresses many of the adaptation-associated changes in gene expression, including those previously associated with CDK4/6 inhibitor resistance, suggesting that CDK8/19 inhibition may greatly extend the therapeutic benefit of CDK4/6 inhibitors.

Zachary T Mack, M. Yastrebova, Chang-uk Lim et al. · Cell Reports Medicine · 0 citations