Open access
Jul 2026
CX3CR1+ macrophages aggravate doxorubicin-induced cardiomyopathy by impairing cardiac mitophagy via the CSF1R-PARP1-IL1B axis.
A novel mechanism through which Cx3cr1+ macrophages regulate cardiomyocyte function via the CSF1R-PARP1-IL1B-mitophagy signaling axis is unveiled, providing a new theoretical foundation and intervention strategy for doxorubicin-induced cardiomyopathy targeted therapy.
Yiping Shi, Long Chen, Yuxiao Feng et al.
· Autophagy · 0 citations