Author

Guo-Yuan Wen

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Review Open access Sep 2026

Phospholipid codes at virus-host membrane interfaces: mechanisms and therapeutic opportunities in animal viral diseases

Animal viruses depend on host membranes at every stage of infection, yet membrane lipid states are often treated as background rather than as causal determinants of virus-host interactions. This Review develops a phospholipid-code framework in which headgroup identity, acyl-chain chemistry, leaflet topology, and lipid...

L. Tan, Guo-Yuan Wen · Frontiers in Cellular and In... · 0 citations

Open access Sep 2026

A recombinant Newcastle disease virus-vectored multi-epitope vaccine confers protection against QX-like infectious bronchitis virus in chickens

Protection was accompanied by an increased frequency of splenic CD3 + CD8 + T cells, particularly after booster immunization, suggesting a role for cellular immunity alongside neutralizing antibodies.

Fei Wang, Jia-Nan Xie, Guo-Yuan Wen et al. · Frontiers in Immunology · 0 citations

Aug 2026

A novel TK/gE-deleted pseudorabies virus vaccine expressing CCL3L1 enhances humoral immunity by stimulating the dendritic cell-T follicular helper-germinal center axis.

Results demonstrate that CCL3L1 acts as an effective molecular adjuvant by potentiating humoral immunity through activation of the conventional DC-T follicular helper cell-GC B cell axis, supporting HNX-ΔTK/ΔgE-CCL3L1 as a potential vaccine for the control of emerging PRV variants.

Lun Yao, Si-Wen Hao, Chengjun Zhang et al. · Veterinary Microbiology · 0 citations