Author

Guo-Zhen Chen

2 papers indexed here

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Open access Sep 2026

Honokiol Alleviates Dry Eye-Related Corneal Epithelial Damage by Activating SIRT3/PINK1-Mediated Mitophagy

This study demonstrates that HKL protects against dry eye-associated corneal epithelial damage potentially through a mechanism involving SIRT3 modulation and PINK1-mediated mitophagy, offering a potential therapeutic strategy for dry eye disease.

Yu-Lei Huang, Xin-Dan Cao, Xin-Lin Yan et al. · Drug Design, Development and... · 0 citations

Open access Aug 2026

An ICD gene set-derived immune contexture signature for colorectal cancer prognosis: integrated single-cell and bulk transcriptomic analysis with external validation.

Immunogenic cell death (ICD) links tumor cell demise with antitumor immunity, but the transcriptional features associated with ICD gene expression patterns and their prognostic significance in colorectal cancer (CRC) remain areas of active investigation. This study integrated single-cell and bulk transcriptomic data fr...

Shu-Qiong Su, Guo-Zhen Chen, Shi-Yao Yang et al. · Cancer Treatment and Researc... · 0 citations