Author

Guo-Can Yu

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Open access Oct 2026

Supramolecular Pretargeting Lipid Nanoparticles Based on Host-Guest Recognition Potentiate Cancer Immunotherapy by Reprogramming Tumor Microenvironment.

CN-LNPs are employed as a delivery platform to encapsulate a circular RNA encoding IL-2-Fc fusion protein, enabling intratumoral cytokine production to potentiate antitumor immunity and establish a versatile platform that overcomes the intratumoral delivery limitations commonly associated with conventional LNPs system.

Jin-Qun Gan, Yang-Fan Wang, Meng-Yao Li et al. · Angewandte Chemie · 0 citations

Open access Jul 2026

Split intron-exon system for circular RNA synthesis

The split intron-exon (SIE) system is introduced, which separates ribozymes from substrates to facilitate the efficient production of modified circular RNAs, optimizing production process.

Lei Wang, Qiaoli Zhai, Chunbo Dong et al. · Nature Communications · 0 citations