Author

Guoyan Zhao

2 papers indexed here

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Open access Jun 2026

Unlocking cis-regulatory landscapes across 500 million years of evolution and disease mechanisms

Abstract Genomic DNA encodes regulatory information that determines where, when, and to what extent genes are expressed. Theoretically, we should be able to identify these transcriptional “instructions” by examining genomic DNA sequence alone, yet this has remained challenging. Here we present the Vertebrate Regulatory...

Tássia Mangetti Gonçalves, Casey L. Stewart, Samantha D. Baxley et al. · NAR Genomics and Bioinformat... · 0 citations

Open access Aug 2026

Core activation program and selective regional responsiveness of microglia during aging and parabiosis.

Aging is associated with immune dysregulation in the brain and is the greatest risk factor for many neurodegenerative diseases. Rejuvenation interventions can mediate beneficial effects. Microglia are major contributors to neurodegenerative disease progression; however, the molecular changes underlying brain aging and...

H. Naz, Nannan Lu, Caroline C. Escoubas et al. · Cell Reports · 0 citations