To evaluate the indications, surgical outcomes, and diagnostic role of pars plana vitrectomy (PPV) in uveitis of diverse etiologies. This retrospective study included 32 eyes (30 patients) undergoing 23-gauge PPV during 2019–2025. Uveitis etiology, surgical indications, and pre- and postoperative best-corrected visual acuity (BCVA) were analyzed. The primary outcome was change in BCVA, while secondary outcomes included anatomical success in retinal detachment (RD) cases, clinically meaningful visual improvement, diagnostic yield, and postoperative complications. The most common etiologies were idiopathic uveitis (16.7%) and suspected primary vitreoretinal lymphoma (16.7%). Main surgical indications included tractional RD (28.1%), rhegmatogenous RD (21.9%), and diagnostic vitrectomy (18.8%). Final anatomical success was achieved in 93.8% of RD cases. BCVA improvement remained statistically significant at 1, 6, and 12 months after correction for multiple comparisons, while a gain of ≥ 2 Snellen lines was achieved in 46.2% of eyes at the final follow-up visit. No severe postoperative inflammation occurred. PPV is a safe and effective approach for managing vitreoretinal complications and diagnostic evaluation in uveitis, with favorable anatomical and functional outcomes.
Nilufer Zorlutuna Kaymak, H. Kanar, Güzide Akçay et al.· BMC Ophthalmology· 0 citations
The findings underscore the importance of preserving macular attachment, minimizing surgical delay, and recognizing PVR as a key determinant of both functional recovery and recurrence in optimizing outcomes after PPV for RRD.
Güzide Akçay, U. Kıvrak, I. Karagöz et al.· Southern Clinics of Istanbul...· 0 citations
Purpose: The purpose of the study was to evaluate the anatomical and functional outcomes of the inverted internal limiting membrane (ILM) flap technique in patients with large macular holes (MHs) and identify independent prognostic factors that predict post-operative visual acuity. Methods: This retrospective study included 48 eyes of 48 patients who underwent pars plana vitrectomy and inverted ILM flap technique for idiopathic MHs ≥400 μm. Pre-operative and post-operative best-corrected visual acuity (BCVA), swept-source optical coherence tomography (SS-OCT) parameters, and various clinical factors were evaluated. Multivariate regression analysis was performed to identify independent prognostic factors for the post-operative BCVA. Results: The mean BCVA improved significantly from 1.27±0.41 logMAR preoperatively to 0.62±0.37 logMAR at 6 months postoperatively (p<0.001). U-shaped closure was associated with better BCVA than V-and W-shaped closures (p=0.001). Patients with symptom duration ≤6 months and complete post-operative restoration of the external limiting membrane (ELM) and ellipsoid zone demonstrated significantly better BCVA (p<0.01). Pre-operative BCVA (β=0.637, p<0.001) and MH index (MHI) (β=−0.261, p=0.029) were significant independent determinants of post-operative BCVA. Conclusion: The inverted ILM flap technique provides high anatomical closure rates and significant visual improvement in large MH surgery. Pre-operative BCVA and MHI were significant independent prognostic factors for post-operative visual outcomes. Structural SS-OCT parameters can be clinically useful in predicting post-operative functional outcomes
Güzide Akçay, Dilber Celik Yaprak, U. Kıvrak et al.· European Eye Research· 0 citations