Advancements in Forecasting Liver Cytosol Metabolic Stability: A Comprehensive Update on Machine Learning Predictive Models
Drug metabolism plays a key role in determining a compound’s pharmacokinetics and overall success in development. While cytochrome P450 enzymes have been widely studied, non-cytochrome P450 enzymes, such as aldehyde oxidase, xanthine oxidase, and carboxylesterases, are increasingly recognized as important contrib...