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Open access Sep 2026

N,N-Dimethyltryptamine and harmine formulation alters transient EEG topography sequences near the peak of the psychedelic state.

BACKGROUND Psychoactive serotonin 5-HT2A receptor agonists are potent modulators of awareness. Influential theories propose that psychedelics alter whole-brain dynamics by increasing neural signal diversity and dynamic flexibility. Beyond temporal variability, it is an open question whether psychedelics impact the char...

Maria Niedernhuber, D. Suay, Bigna Lenggenhager et al. · 0 citations
Review Aug 2026

Salvinorin A in humans: A systematic review of pharmacokinetics, pharmacodynamics, and safety.

Salvinorin A, the principal psychoactive constituent of Salvia divinorum, is a highly selective κ-opioid receptor agonist and a rare example of a κ-opioid receptor-mediated psychedelic drug. Preclinical work of salvinorin A has shown promising effects in neuropsychiatric animal models. However, human studies remain het...

Wolfgang Emanuel Zürrer, J. Liesner, David Brüschweiler et al. · 0 citations

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