H. Alfassam

Green-Synthesized Copper Oxide-Modified Serpentine Nanocomposite for Efficient Adsorptive Removal of Malachite Green Dye: Mechanism, Thermodynamics, and Waste-to-Energy Valorization via Urea Electro-Oxidation

Malachite green (MG), a triarylmethane dye extensively used in the textile and aquaculture industries, is a persistent aquatic contaminant with documented carcinogenic, mutagenic, and teratogenic effects even at trace concentrations. In the present work, a natural, low-cost Serpentine clay was surface-modified with cop...

Engineering a chitosan-based nanoemulsion for non-invasive CNS-targeting approach: dual neuroprotection against epileptic and depressive disorders.

Enhanced antimicrobial effect of thyme oil nanoemulsion combined with Lactobacillus acidophilus La-5 against Listeria monocytogenes in laboratory-prepared soft cheese

The development of natural and sustainable preservation strategies is important for improving food safety, extending shelf life, and reducing reliance on synthetic additives in dairy products. This study evaluates the antimicrobial effectiveness of thyme oil nanoemulsion and Lactobacillus acidophilus La-5, individually...

Experimental and Monte Carlo Insights into the Biofilm Control of Klebsiella pneumoniae Using Green-Synthesized Ag/Ni(OH)2/Clove Nanocomposites

One of the most significant challenges with disease control in humans and animals is biofilm formation by Klebsiella pneumoniae (K. pneumoniae). The current study investigated the prevalence of K. pneumoniae in fecal and milk samples from cattle and humans, along with their antimicrobial susceptibility patterns and bio...

Breaking the Myb–KIX Alliance: Structure‐Guided Discovery of Biaryl Hydroxy‐Naphthamides as Disruptors of the c‐Myb–CBP/p300 KIX Protein–Protein Interaction

3‐hydroxy‐2‐naphthamides are established as promising scaffolds for targeting the c‐Myb–CBP/p300 KIX interface and are supported as the most conformationally stable interfacial binders.

Targeting the c-Myb-CBP/p300 KIX protein-protein interaction with quinone-methide triterpenes: In silico mechanistic insights and MST biochemical validation.

Tingenone is identified as a promising scaffold for the development of new c-Myb-CBP/p300 KIX PPI inhibitors, having produced the clearest signatures of interfacial weakening and the most favorable disruption metrics.

Structure-guided delineation of umbelliferyl phosphate-based disruptors of the c-Myb-CBP/p300 KIX protein-protein interaction.

The interaction between c-Myb and the CBP/p300 KIX domain is a critical transcriptional regulatory event and an attractive target for the development of candidate disruptors of the recombinant c-Myb-KIX interaction. In this study, we used an integrated computational and experimental strategy to identify new small molec...