Author

H. Algül

2 papers indexed here

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Open access Sep 2026

Targeting Kras signalling in a Trp53/KrasG12D mouse and organoid model inhibits Barrett esophagus to gastroesophageal adenocarcinoma progression

The lack of experimental systems that faithfully model the genetic and phenotypic progression from Barrett’s esophagus (BE) to gastroesophageal adenocarcinoma (GEAC) has limited mechanistic discovery and preclinical testing. Here, we report a refined L2-IL-1B based mouse model engineered to capture two hallmark alterat...

Akanksha Anand, Linus R. Schoemig, Lioba Klaas et al. · Scientific Reports · 0 citations

Open access Jul 2026

LSD1-GLS2 axis drives subtype-specific chemoresistance in pancreatic cancer through glutaminolysis reprogramming

It is shown that LSD1 knockdown has opposing, subtype-specific effects on chemotherapeutic responses: it sensitized RSK-subtype cells to chemotherapy but induced resistance in KRAS-subtype cells, revealing mitochondrial dysfunction and defective mitophagy as hallmarks distinguishing KRAS- from RSK-subtype PDAC.

Zhe-Fang Wang, Qiu Huang, Jian-Gang Zhao et al. · Cell Death and Disease · 1 citation