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Author

H. Alsaad

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Open access Sep 2026

Design and In Silico Evaluation of Novel 1,3,4-Oxadiazole Derivatives as Potential CYP51B Inhibitors Against Aspergillus fumigatus

Antifungal resistance and invasive fungal infections remain the major therapeutic issues, especially in patients with impaired immune systems. Aspergillus fumigatus is the main cause of invasive aspergillosis and sterol 14-α-demethylase (CYP51B), a key enzyme in the biosynthetic pathway of ergosterol, is an important t...

Shams Khaleel Ibraheem, B. A. Abdrazik, H. Alsaad et al. · 0 citations
Open access Sep 2026

1,3,4-Oxadiazole derivatives as potential anti-glioma agents: synthesis, characterization, in vitro cytotoxic activity against HS683 cells, and molecular docking

The results position B2 as a lead compound for further development as an anti-glioma agent and Molecular docking against PI3Kα, CDK2, and FAK suggested possible binding modes for the active compounds.

Rabab Jameel Hashim, H. Alsaad, Husam Hamza Salman · 0 citations

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