H. Alshareef

Bis-thiosemicarbazone derivative as starting agent for synthesis of anti-breast cancer agents and targeting PIM-1 kinase.

AIMS To design, synthesize, and biologically evaluate novel bis-thiazole derivatives as potential PIM-1 kinase inhibitors for breast cancer therapy. MATERIALS AND METHODS A series of new bis-thiazole derivatives were synthesized and evaluated for their antiproliferative activity against MDA-MB-231 and MCF-7 breast ca...