Patients with Alzheimer’s disease (AD) and clinically overlapping neurodegenerative diseases are classified molecularly using the A/T/N classification system. Apart from fluid biomarkers and structural MRI, A/T/N assessment incorporates β-amyloid-PET (A), tau-PET (T), and [18F]FDG-PET (N). We evaluated if dynamic featu...
Johannes S. Gnörich, J. Kusche-Palenga, Agnes Kling et al.· Molecular Neurodegeneration· 0 citations
Differential associations of age and AD pathology with mesoscale MTL-connectivity patterns show differential associations of age and AD pathology with mesoscale MTL-connectivity patterns, which may support memory function in the short term while contributing to subsequent memory decline.
Larissa Fischer, N. Vockert, Joseph Höpker Fernandes et al.· bioRxiv· 0 citations
Episodic memory decline is a common feature of cognitively normal aging, but its extent varies markedly across individuals. Although entorhinal tau pathology is thought to be a key contributor to episodic memory impairment, the neural mechanisms linking early tau accumulation to memory differences remain unclear. Grid-...
V. Segen, Tuğçe Belge Bernard, Gerard Callau Navarro et al.· bioRxiv· 0 citations
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