Abstract The development of liver metastases in prostate cancer is associated with aggressive disease and poor prognosis. Because hepatocytes exhibit high metabolic activity with unique secretory profiles, we hypothesized that hepatocyte-to-tumor cell signaling plays a role in promoting liver metastasis. We evaluated s...
Jacob Egelberg, Rebecca Kim, M. J. Kim et al.· Cancer Research Communicatio...· 0 citations
Phenotypic plasticity is a recognized mechanism of therapeutic resistance in prostate cancer (PCa); however, current knowledge of its underlying drivers and therapeutic interventions remain limited. Using genetically engineered mouse models (GEMMs) devoid of Pten and Rb1, we previously demonstrated the chromatin reprog...
Beatriz German, K. Morel, Teia Noel et al.· Cell Reports Medicine· 0 citations
Delta-like ligand 3-directed therapies may reshape the management of DLL3-expressing prostate cancer if ongoing efforts to refine biomarkers improve patient enrichment and optimize trial design are successfully translated into clinical practice.
Giovanna Pecoraro, A. De Giorgi, G. Montelatici et al.· Drugs· 0 citations
Accurate identification of cell types and states is essential for reliable single-cell RNA-sequencing analyses, yet current methods remain sensitive to continuous biological states, data preprocessing choices, and reference selection. Here we present ClustoCell, a reference-free method that resolves cell identity using...
Abbas Salavaty, M. Foroutan, N. Pretel et al.· bioRxiv· 0 citations
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