Author

H. Blasco

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Open access Aug 2026

Intrabody B1 targeting TDP-43 modulates neuroinflammatory and metabolic pathways in a preclinical ALS model

Collectively, scFv B1 modulates upstream pathogenic processes associated with TDP-43 proteinopathy but is insufficient to reverse established neurodegeneration after symptom onset, underscoring the need for earlier and likely combinatorial intervention strategies in ALS.

Y. Al Ojaimi, A. Dupuis, M. Palla et al. · Neurotherapeutics · 0 citations

Review Open access Aug 2026

ALS: An Organism-Wide Bioenergetic Failure Due to Mitochondrial Dysfunctions?

Targeting upstream mechanisms of mitochondrial impairment may provide a unifying strategy for understanding ALS pathogenesis and developing effective therapies.

Hiroshi Mitsumoto, H. Blasco, P. Corcia et al. · Biomolecules · 0 citations