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Open access Sep 2026

Neuroprotective effects of empagliflozin and metformin combined therapy on rotenone induced Parkinsonism in Wistar rats via PI3K and PPARγ modulation

It is suggested that combined metformin and empagliflozin therapy exerts enhanced neuroprotective effects through modulation of protein aggregation pathways, highlighting a promising drug-repositioning strategy for Parkinsonism.

Marwa M. Mona, H. Borg, Al-Shimaa A. Ahmed et al. · 0 citations

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