Elevated IGF-1 levels are associated with accelerated bone age advancement during growth hormone therapy in children: a multicenter cohort study
Background Elevated insulin-like growth factor-1 (IGF-1) levels are associated with earlier pubertal onset and accelerated bone maturation. However, the effect of IGF-1 increases during growth hormone (GH) therapy on bone age (BA) advancement across different etiologies of short stature remains unclear. Methods This mu...