Alpha-ketoglutarate ameliorates systemic sclerosis-associated fibrosis by restoring endothelial function.
Systemic sclerosis (SSc) is a devastating autoimmune disease characterized by multi-organ fibrosis with limited therapeutic options. Using targeted metabolomics, we first observed that levels of alpha-ketoglutarate (α-KG), a key TCA-cycle intermediate, were paradoxically elevated in bleomycin-induced fibrotic lungs and...