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Open access Oct 2026

Alpha-ketoglutarate ameliorates systemic sclerosis-associated fibrosis by restoring endothelial function.

Systemic sclerosis (SSc) is a devastating autoimmune disease characterized by multi-organ fibrosis with limited therapeutic options. Using targeted metabolomics, we first observed that levels of alpha-ketoglutarate (α-KG), a key TCA-cycle intermediate, were paradoxically elevated in bleomycin-induced fibrotic lungs and...

Yan-Ting Wu, Shi-Kai Ye, Huan-Ling Chen et al. · 0 citations
Open access Aug 2026

A compact five-gene immuno-fibrotic profile distinguishing systemic sclerosis subtypes with PXDN validated as a fibrosis-associated target

The integrative analysis identifies a concise immunofibrotic gene signature that robustly distinguishes SSc and its major subtypes, highlighting a potential nexus of immune-stromal interactions that may underlie disease heterogeneity, offering candidate biomarkers for molecular stratification and therapeutic targeting.

Xiang-Yue Zhao, Ke-Jian Hu, Yin-Zhi Cui et al. · 0 citations

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