Emergence of Disease-relevant Aberrant Epithelial Cell States in Human Alveolar Organoids.
How primary human alveolar epithelial organoids respond to a commonly-used commercial alveolar differentiation media intended to facilitate AT2->AT1 differentiation (ADM) in isolation and following biased HIF activation is investigated to position HIF2 as a critical potentiator of aberrant alveolar epithelial cell stat...