Genome-wide association studies of alcohol use disorder (AUD) have identified >100 loci, yet the functional impact and the downstream molecular mechanisms are not well understood. As functional effectors of genes, proteins provide direct insight into disease mechanisms. However, most proteomic alterations in postmortem...
Xin-Di Li, Andrew J. Boreland, Arpana Agrawal et al.· bioRxiv· 0 citations
It is shown that chronic alcohol consumption promotes an overall increase of intron retention in the brain and is associated with the presence of double-stranded RNA, which may contribute to neuronal loss and brain pathology by activating a neuroinflammatory response.
Ru-Dong Li, Jill L. Reiter, Season K. Wyatt-Johnson et al.· Brain Communications· 0 citations
Gradients across socioeconomic status (SES) exist across most health conditions. While there has been significant attention devoted to the relationship between SES and physical and mental health, less research has examined how these relate to substance use disorders (SUD). In the current study, we use data from the pro...
Peter B. Barr, Megan E. Cooke, S. Kuo et al.· medRxiv· 0 citations
PGS demonstrated clinically meaningful risk prediction for substance use disorders in EA and LA, supporting the feasibility of future clinical implementation for population-level screening and underscoring the urgent need for more genetic studies in that population.
Dong-Bing Lai, Michael Zhang, Tae-Hwi Schwantes-An et al.· medRxiv· 0 citations
Having a spouse with higher PGSPAU was associated with higher AUDcrit and the social genetic effect of spousal PGSPAU was stronger among male target individuals, highlighting the potential importance of social genetic effects for understanding the pathways from genotype to alcohol use disorder.
S. Kuo, V. McCutcheon, F. Aliev et al.· Alcohol, clinical & experime...· 0 citations
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