Abstract B121: Induction of Immunogenic Cell Death in Pancreatic Ductal Adenocarcinoma by a Sigma-2 Ligand–Conjugated xCT Inhibitor
Pancreatic ductal adenocarcinoma (PDAC) remains highly lethal and is largely resistant to current immunotherapy approaches, in part because of a profoundly immunosuppressive tumor microenvironment (TME) that limits antigen presentation and effector immune cell activity. Immunogenic cell death (ICD) is a regulated...