Author

H. Farin

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Sep 2026

Isoform-Selective Targeting of Akt Through Covalent Allosteric Inhibition.

Developing selective covalent-allosteric Akt inhibitors targeting Akt2 and Akt3 while sparing Akt1 is reported, which establishes a framework for the development of isoform-selective therapeutics and highlights the potential for unraveling isoform-specific functions in signaling pathways relevant to cancer biology.

G. D'Angelo, Kosmas Alexandros Pervanidis, Ioannis Athanasiadis et al. · Angewandte Chemie · 1 citation