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Author

H. Fayed

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Aug 2026

Remogliflozin Attenuates Thioacetamide-Induced Nephrotoxicity: Association with Nrf2/HO-1, SIRT1/AMPK, and TLR4/NF-κB Pathway Modulation.

Thioacetamide (TAA) induces renal injury via oxidative stress and inflammation. Remogliflozin (Remo), an SGLT2 inhibitor, was evaluated for potential renoprotection. Twenty-four male Wistar rats were assigned to control, TAA (100 mg/kg IP twice weekly), TAA + Remo 25 mg/kg, or TAA + Remo 50 mg/kg (oral daily). Outcomes...

Marwa M. Qadri, D. Almarghalani, Abdulaziz Alarifi et al. · 0 citations
Aug 2026

Linagliptin attenuates cisplatin-induced cardiotoxicity in rats via modulation of the SIRT1/AMPK/Nrf2 signaling pathway

Linagliptin demonstrates potent cardioprotective effects against cisplatin-induced toxicity, primarily through modulation of the SIRT1/AMPK/Nrf2 signaling pathway, thereby resulting in reduced oxidative stress and inflammation.

M. Alsugoor, Naif Al Suhaymi, Bassim M S A Mohamed et al. · 0 citations
Open access Jan 2026

Protective Role of Linagliptin in Cisplatin‐Mediated Liver Injury: Involvement of STAT3 and AMPK/SIRT1/PGC‐1alpha Mitochondrial Energy Sensing Networks

The results indicate that Lina protects against Cis‐induced liver damage by leveraging its antioxidant, anti‐inflammatory, and metabolic regulation properties.

M. A. Elbaset, Bassim M S A Mohamed, Passant E. Moustafa et al. · 0 citations

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