Author

H. Fung

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Open access Aug 2026

Conserved catalytic motifs encode enzyme-like supramolecular peptide assemblies

The findings establish conserved catalytic motifs as a rich source of functional catalysts and demonstrate that they encode sufficient information to construct highly active supramolecular active sites independently of the globular protein fold demonstrate that complex catalytic function can emerge from remarkably simp...

Liam R. Marshall, Sagar Bhattacharya, Leonardo F. Serafim et al. · Research Square · 0 citations

Open access Jul 2026

Preclinical characterization of a reversible XPO1 inhibitor for cancer therapy

The authors design and characterise FR-027, a reversible covalent inhibitor of XPO1 that does not induce XPO1 degradation, demonstrating strong antitumour activity, including in brain tumours, with an improved safety profile in mice.

Janne Van Hauwenhuyse, F. Reniers, L. Persoons et al. · Nature Communications · 0 citations