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Author

H. Grosshans

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2 papers indexed here

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Open access Oct 2026

Large transgene arrays cause aberrant transcription and synthetic molting defects.

Multicopy transgene arrays remain widely used in Caenorhabditis elegans research. It is usually assumed that they behave neutrally, not impacting the phenotype under investigation. Here, we reveal that a previously reported heterochronic extra-molt phenotype associated with myrf-1(mg412) depends on the presence of the...

Iskra Katic, Panagiotis K. Papasaikas, Dimos Gaidatzis et al. · 0 citations
Open access Aug 2026

let-7 miRNA and lin-46 mRNA are essential targets of the LIN28 RNA-binding protein in Caenorhabditis elegans developmental timing regulation

The RNA-binding protein (RBP) LIN28 is a key regulator of temporal cell fates, promoting stem cell identity and suppressing differentiation. It regulates the processing of the let-7 miRNA but additionally binds thousands of mRNAs, suggesting a model of coordinated regulation across many targets. Yet, direct evidence fo...

Jana Brunner, Anca Neagu, Dimos Gaidatzis et al. · 0 citations

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