Author

H. Guo

2 papers indexed here

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Open access Sep 2026

Causal roles of phenotypic age and metabolic health on dementia: a Mendelian randomisation and structure learning study

Lower lymphocyte percentage and higher NMR-derived glucose had direct relationships with dementia in the joint constituent-biomarker network, supporting examination of composite exposures alongside their constituent biomarkers.

A. Baousi, K. Dobinda, J. Zhu et al. · medRxiv · 0 citations

Open access Sep 2026

Genetic Architecture and Sample Size Impact Relative Performance of Nonlinear Machine Learning and Standard Polygenic Risk Scores

Standard polygenic risk scores (PRSs) are constructed based on additive genome-wide association study (GWAS) summary statistics. Nonlinear machine learning methods have been increasingly applied to construct PRSs directly from individual-level data, with the aim of improving predictive performance over standard PRSs th...

J. Zhu, A. Baousi, A. P. Morris et al. · medRxiv · 0 citations