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H. Hagihara

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Open access Sep 2026

350. Transcriptomic analysis of mouse brain tissue demonstrates similarity between sleep deprivation and neuronal hyperexcitation-induced gene expression

Abstract Background Sleep deprivation is associated with numerous health problems and has been linked to neuronal hyperexcitation, a potential driver of its neurological harm. Aims & Objectives This study aimed to elucidate the transcriptomic relationship between sleep deprivation and neuronal hyperexcitation. Method T...

M. M. Chatzigiannis, H. Hagihara, T. Miyakawa · 0 citations
Open access Jul 2026

Repetitive neuronal activation regulates cellular maturation state via nuclear reprogramming

Repeated stimulation of dentate gyrus neurons in mice reverts post-mitotic mature neurons to an immature-like state through reactivation of cell-cycle-like programs—a previously unrecognized form of cellular plasticity termed “nuclear reprogramming.”

Tomoyuki Murano, H. Hagihara, K. Tajinda et al. · 3 citations

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