H. Hirai

The gene expression signature of multinucleated giant cells in the spleens of Leishmania donovani-infected mice.

Multinucleated giant cells (MGCs) are associated with chronic inflammation and infectious diseases, but their biological characteristics in vivo remain poorly understood because intact cells are difficult to isolate from tissues. In visceral leishmaniasis, heavily parasitized, hemophagocytic MGCs are observed in the sp...