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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

H. Huckstep

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Open access Sep 2026

Personalized phosphoproteomics establish mTORC1 as a regulator of exercise-induced insulin sensitization in human skeletal muscle

Exercise enhances skeletal muscle insulin sensitivity, but the signaling mechanisms responsible are poorly understood. Understanding them may open new therapeutic avenues for individuals with limited exercise capacity. Here, we used rapamycin to inhibit mTORC1 in combination with exercise and insulin stimulation in hea...

Magnus R. Leandersson, H. Huckstep, J. Onslev et al. · 0 citations
Open access Aug 2026

High-throughput screening in hiPSC-cardiac models reveals cardiomyocyte-specific cell cycle regulatory mechanisms

A dual-reporter and a high-throughput image-based pipeline are developed and a cardiomyocyte-selective pro-proliferative compound is identified as GDC-0339, uncovering cardiomyocyte-specific mechanisms governing the cell cycle that are potentially druggable.

Francesca Butera, Bryce Hassett, Rachel Morris et al. · 0 citations
Open access Aug 2026

Alpha protein kinase 3 gene therapy restores heart function in mouse and human models of cardiomyopathy

It is demonstrated that adeno-associated virus-mediated delivery of full-length human ALPK3 prevents cardiomyopathy in neonatal mouse models and reverses established disease in adult mice, restoring cardiac structure, function and proteostasis, as well as contractile function in human cardiac organoids carrying ALPK3-...

James W. McNamara, Ellen B. Keen, Rebecca Sutton et al. · 2 citations

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