Oct 2026
CEBPB integrates OSM signaling and eIF4G2-mediated alternative translation to configure enhancer landscape and sustain oncogenic CHI3L1 in glioblastoma.
BACKGROUND CEBPB is a critical driver of mesenchymal transformation and aggressiveness in glioblastoma (GBM). However, fundamental questions remain regarding its dynamic regulation within the GBM microenvironment and its precise mechanistic role in orchestrating the epigenetic and transcriptional reprogramming. METHO...
Ji-Yang Liu, Ying Zhang, Xiao-Ping Yi et al.
· Neuro-Oncology · 0 citations