The human brain develops and matures over an exceptionally prolonged period of time that spans nearly two decades of life. Processes that govern species-specific aspects of human postnatal brain development are difficult to study in animal models1. While human brain organoids offer a promising in vitro model, they have...
Many epigenetic regulators play essential roles in animal development, but precisely how they function across different cell types without clear sequence preferences remains a foundational challenge. Here, we employed single-cell RNA sequencing to survey the mutant phenotypes of 30 essential regulatory pathways across...
Yusuke Kijima, JoAnne Villagrana, Min-Ming Wang et al.· bioRxiv· 0 citations
Deep whole-genome bisulfite sequencing data from blood samples of 120 healthy donors revealed only limited association between age-associated epigenetic alterations in DNA methylation, chromatin accessibility, and histone modifications, arguing against a broadly coordinated remodeling of the aging epigenome.
M. Steiger, René Krüger, Mina Shaigan et al.· bioRxiv· 0 citations
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