Author

H. Kubota

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Open access Oct 2026

Developmental prefrontal myelination shapes inhibitory interneuron function and adult social behavior

Early-life adversity and abnormal myelination are implicated in psychiatric disorders, but how developmental myelination influences adult social cognition remains unclear. Here, we tested whether disrupting developmental myelination in the medial prefrontal cortex (mPFC) impairs adult social behavior. Using complementa...

Takahira Yamauchi, Kohei Kamikawa, Kazuhiko Yamamuro et al. · bioRxiv · 0 citations

Open access Sep 2026

425. Maternal immune activation induces neurodevelopmental impairments of adult offspring through alterations in tryptophane-kynurenine pathway in the placenta

Abstract Background Maternal immune activation (MIA) is recognized as one of the significant environmental risk factors for neuropsychiatric disorders such as schizophrenia in adult offspring. However, the pathophysiological mechanisms remain unknown. Aims & Objectives The tryptophan (TRP)-kynurenine (KYN) pathway, inf...

A. Mouri, M. Hasegawa, M. Niijima et al. · International Journal of Neu... · 0 citations