Beyond Amyloid: Hippocampal Atrophy as a Prognostic Marker in Amyloid-Negative Subjective Cognitive Decline
The emergence of blood-based biomarkers (BBMs) has transformed the diagnosis of Alzheimer’s disease (AD). 1,2 Plasma phosphorylated tau, glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL) have demonstrated remarkable accuracy in detecting amyloid pathology and predicting disease progression acr...