H. Lauterbach

Innate immune activation profiles are associated with polarization of the T cell response to recombinant arenaviral vectors

Arenavirus-based vectors are uniquely positioned to generate durable T cell responses against tumors, which remains a central challenge in cancer immunotherapy. Two members of the arenavirus family, Lymphocytic choriomeningitis virus and Pichinde virus, were genetically engineered to encode a non-oncogenic fusion prote...