Author

H. Lehmler

3 papers indexed here

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Open access Sep 2026

ALDH1/2 deficiency modulates dieldrin-induced dopaminergic neurodegeneration and reactive glial morphometry in male mice

The etiology of Parkinson’s disease (PD) is associated with exposure to environmental contaminants, including the organochlorine pesticide dieldrin. This is thought to occur through induction of oxidative damage and dysregulation of dopamine homeostasis via impairment of aldehyde dehydrogenase (ALDH) enzymes, resulting...

Omar A. Yanouri, Adam J. Schuller, Savannah M. Rocha et al. · Frontiers in Toxicology · 0 citations

Open access Oct 2026

Pulmonary Proteomic Responses to Subacute 2,2′,5,5′-Tetrachlorobiphenyl-4-ol Exposure via a Subcutaneous Implant in Adolescent Female Rats

Hydroxylated polychlorinated biphenyls (OH-PCBs) are biologically active metabolites that may contribute to adverse respiratory outcomes, yet their effects on the developing lung remain poorly characterized. This study investigated the impact of 2,2′,5,5′-tetrachlorobiphenyl-4-ol (4-OH-PCB52), a human-relevant metaboli...

Crystal M. Roach, Hui Wang, Nate R. Koester et al. · Journal of Xenobiotics · 0 citations

Open access Aug 2026

Expression of the Human R163C-RYR1 Gain-of-Function Mutation Modified 2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) Developmental Neurotoxicity in Weanling Mice

It is demonstrated that PCB 95 caused behavioral deficits coincident with altered patterns of basal and training-induced dendritic arborization and behavioral and dendritic responses to PCB 95 were altered by expression of the human R163C-RYR1 gain-of-function mutation, supporting the involvement of RYR1-dependent mech...

Christopher D. Barnhart, Rebecca J. Wilson, S. Sethi et al. · International Journal of Mol... · 0 citations