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Open access Oct 2026

Functional fine-mapping of the 9p21.3 cardiovascular disease locus implicates the lncRNA MIR31HG as an effector transcript in endothelial cells

BACKGROUND: The chromosome 9p21.3 locus is among the strongest genetic risk loci for cardiovascular disease (CVD), yet the regulatory mechanisms underlying this association remain poorly understood. Previous vascular disease studies focused predominantly on the role of this locus in smooth muscle cell (SMC) dysfunction...

A. Zhigulev, F. Poujade, N. Gryzunov et al. · 0 citations
Open access Oct 2026

Adipokines and perivascular adipose tissues in coronary artery disease: depot-specific adipokine expression, adipocyte morphology, and links to metabolic dysfunction

Perivascular adipose tissue (PVAT) modulates vascular function through paracrine adipokine secretion and undergoes proinflammatory remodeling in coronary artery disease (CAD) and metabolic dysfunction. Depot-specific differences in adipokine expression and adipocyte morphology remain incompletely characterized. Sixty C...

L. Hartmann, K. Buschmann, N. Kastner et al. · 0 citations

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