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H. Muhle

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Open access Aug 2026

STX1B variant-specific synaptic dysfunction is associated with network hyperexcitability in human iPSC-derived neurons

The divergence between morphological, electrophysiological and transcriptomic findings suggests that compensatory mechanisms may contribute to network hyperexcitability, and the graded severity of network alterations across STX1B variants correlates with the clinical phenotypes.

Carolin Haag, Felix Gsell, Oleg Vinogradov et al. · 0 citations
Open access Aug 2026

Correlation of polygenic risk score and clinical phenotype in patients with genetic generalized epilepsy.

No meaningful association between PRS and age at onset, history of febrile seizures, pre-/perinatal complications, epilepsy syndromes, seizure types, co-occurrence of functional/dissociative seizures, psychiatric comorbidities, electroencephalographic/magnetic resonance imaging findings, or drug response could be demon...

Sophie von Brauchitsch, Nils Hartung, R. Karge et al. · 0 citations

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