Author

H. Nguyen

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Open access Aug 2026

A p53R273H-selective bispecific T cell engager: Computational design and functional validation

TP53 mutations occur in over 50% of human cancers and generate shared neoantigens, including p53R273H, which represents a compelling target for precision immunotherapy. However, HLA allele-specific presentation and the risk of off-target toxicity remain major challenges. Here, we developed a group of bispecific T cell...

Nhan T. Huynh, Thuy Anh Thi Nguyen, Ngoc Thi Bui et al. · Molecular therapy. Oncology · 0 citations

Open access Aug 2026

CALFP-MHC: Interpretable Pan-Allelic Prediction of Peptide-MHC Binding and Presentation Using Chemically Grounded Fingerprints and Contrastive Learning

CALFP-MHC demonstrates that grounding residue representations in molecular chemistry, rather than sequence symbols alone, improves both robustness and interpretability in peptide–MHC binding prediction.

My-Diem Nguyen Pham, T. Ho, H. Nguyen et al. · bioRxiv · 0 citations