Ansamycins (ANs), including rifampicin (RIF), rifabutin (RFB), rifapentine (RPT), rifalazil (RFL), and rifaximin (RFX), are structurally distinctive macrocyclic antibiotics whose analytical determination is complicated by very low systemic exposure (especially RFX), high protein binding and intracellular sequestration...
H. Barzani, R. Omer, A. H. Mer et al.· Analytical Methods· 0 citations
Future progress should shift from isolated improvements in detection sensitivity toward matrix-adaptive, digitally assisted, sustainability-aware analytical systems that integrate automated sample preparation, intelligent data interpretation, robust validation, and lifecycle-based performance assessment.
H. Barzani, R. Omer, Sarbast Naser Ahmed et al.· Journal of chromatography. B...· 0 citations
This critical review comprehensively evaluates the current state of pharmaceutical bioanalysis by examining emerging LC-MS technologies, sustainable analytical strategies, and the growing role of artificial intelligence (AI) and machine learning (ML) in analytical optimization, spectral interpretation, biomarker discov...
H. Barzani, R. Omer, Khalamala Ibrahim Salih Barzani et al.· Analytical Methods· 0 citations
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