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H. Phatnani

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Open access Aug 2026

Distinct Cellular Phenotypes of Language and Executive Decline in Amyotrophic Lateral Sclerosis

SUMMARY Cognitive manifestations, including impairments in language and executive functions, are seen in amyotrophic lateral sclerosis (ALS), but the underlying mechanisms remain unclear. We mapped prefrontal cortex regions from ALS patients by integrating spatial and single-nucleus transcriptomics in a cognitively str...

J. Petrescu, Cláudio Gouveia Roque, Chris Jackson et al. · Cell · 0 citations