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Two Distinct Outbreaks of Extended-spectrum Beta-lactamase-producing Klebsiella Species in a Neonatal and Pediatric Intensive Care Unit in Switzerland.
BACKGROUND Healthcare-associated infections caused by Klebsiella spp. are associated with substantial morbidity and mortality in neonatal and pediatric intensive care units. We describe 2 outbreaks of extended-spectrum beta-lactamase-producing Klebsiella michiganensis and Klebsiella pneumoniae in the same unit. METHO...
Machine learning-guided discovery of a conserved plasmid proteomic signature enables MALDI-TOF MS detection of pOXA-48-carrying Enterobacterales
This approach reframes the resistance prediction task from inferring a resistance phenotype to detecting a conserved plasmid through its expressed proteomic signature and has the potential to enable rapid MALDI-TOF MS-based diagnostics for a wide range of plasmid-based resistance determinants.