Pharmacological targeting of ANO1/TMEM16A in cancer: from channel inhibition to protein downregulation.
Anoctamin 1 (ANO1/TMEM16A) is a calcium-activated chloride channel increasingly recognized as a compelling pharmacological target in oncology. Beyond its role in chloride flux, ANO1 has also been proposed to exert signaling-associated or scaffold-like functions in selected malignancies, including head and neck, breast,...