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Open access Oct 2026

Phytochemical Screening and Protective Effects of Hancornia speciosa Leaf Extract Against Fatty Acid-Induced Lipotoxicity in HepG2 Cells

Hepatic steatosis is the hallmark of metabolic dysfunction-associated steatotic liver disease (MASLD), the most prevalent chronic liver disease worldwide. Lipotoxicity, resulting from excessive accumulation of fatty acids and bioactive lipid intermediates, is associated with increased oxidative stress, potentially lead...

M. Granato, Frank Machado Silva, Vinícius Marques Arruda et al. · 0 citations
Open access Sep 2026

4-Nerolidylcatechol binds to Derlin-1 and modulates endoplasmic reticulum stress markers of androgen-independent prostate cancer cells.

Castration-resistant prostate cancer (CRPC) is a lethal disease characterized by androgen receptor-independent activation mechanisms that promote prolonged or unresolved endoplasmic reticulum (ER) stress. Consequently, these cells rely on the endoplasmic reticulum-associated degradation (ERAD) pathway, specifically Der...

A. Cordeiro, Gabriela da Silva Guimarães, Paula Marynella Alves Pereira Lima et al. · 0 citations

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