Author

H. Tanudisastro

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Open access Oct 2026

Genetic variants shape single-cell chromatin accessibility and disease risk.

Understanding how genetic variation shapes gene regulation at single-cell resolution is crucial for elucidating complex disease mechanisms1, but has been limited by the lack of large-scale single-cell multi-omics data2-4. Here we present single-cell assay for transposase-accessible chromatin with sequencing of 3.5 mill...

A. Xue, Jia-Nan Fan, Oscar A. Dong et al. · Nature · 3 citations

Open access Oct 2026

Rare and common genetic variants shape single-cell immune gene expression.

Understanding the genetic basis of gene expression can shed light on the regulatory mechanisms underlying complex traits and diseases1,2. Single-cell-resolved measures of RNA levels and single-cell expression quantitative trait loci have revealed genetic regulation that drives cell states and types across diverse tissu...

Anna S. E. Cuomo, E. Spenceley, H. Tanudisastro et al. · Nature · 3 citations